Role of S -Adenosylmethionine in Methionine Biosynthesis in Yeast

Role of S-adenosylmethionine in methionine biosynthesis in yeast.

Extracts of Saccharomyces cerevisiae were used to develop a cell-free system capable of converting the beta-carbon of serine into the methyl group of methionine. No requirement for either S-adenosylmethionine or S-adenosylhomocysteine could be demonstrated for net methionine biosynthesis. Growth of the cells in B(12) did not affect the reaction. The mechanism for the methylation of homocysteine...

Role of S-adenosylmethionine in vitamin B12-dependent methionine synthesis.

Biosynthesis of Methionine in Saccharomyces Cerevisiae. Partial Purification and Properties of S-adenosylmethionine: Homocysteine Methyltransferase.

The biosynthesis of methionine from homocysteine may occur by transmethylation or through l-carbon addition from serine via tetrahydrofolate. It has been established that acetothetin, dimethyl-P-propiothetin, and betaine serve as methyl donors for the methylation of homocysteine in mammalian liver (l-3), but these compounds are inactive in microbial systems. The participation of S-adenosylmethi...

The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brain.

OBJECTIVE S-Adenosylmethionine (SAMe) is a major methyl donor in the brain and is also an antidepressant with few reported side effects; however, SAMe is relatively expensive and unstable. Brain SAMe can be increased by giving methionine to rats, raising the possibility that methionine may be an antidepressant. We aimed to study whether SAMe and methionine, when given orally to rats, could rais...

role of cultural iran in promotion of multilaieralism in central asia and caucasus

cultural iran is a scope that is more extended than the political territories of iran as a political unit. this concept means that cultural geography(mehdi moghanlo-1383-1) of iran is greater than its political geography which, according to history, has a long history extending west-east from kandahar to the euphrates and north-south from the persian gulf to the caucasus including transoxiana a...